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1

Evidence-based toxicology: a comprehensive framework for causation

Guzelian, Philip S, Victoroff, Michael S, Halmes, N Christine, James, Robert C, Guzelian, Christopher P

Journal:

Human & Experimental Toxicology

Year:

2005

Language:

english

File:

PDF, 8.38 MB

english, 2005

2

Hepatocellular phenotype in Vitro is influenced by biophysical features of the collagenous substratum

William J. Lindblad, Erin G. Schuetz, Kaye S. Redford, Philip S. Guzelian

Journal:

Year:

1991

Language:

english

File:

PDF, 812 KB

english, 1991

3

Regulation of human liver cytochromes P-450 in family 3A in primary and continuous culture of human hepatocytes

Erin G. Schuetz, John D. Schuetz, Stephen C. Strom, Melissa T. Thompson, Robert A. Fisher, David T. Molowa, Donna Li, Dr. Philip S. Guzelian

Journal:

Year:

1993

Language:

english

File:

PDF, 1.21 MB

english, 1993

4

Regulation of gene expression in adult rat hepatocytes cultured on a basement membrane matrix

Erin G. Schuetz, Donna Li, Curtis J. Omiecinski, Ursula Muller-Eberhard, Hynda K. Kleinman, Barbara Elswick, Philip S. Guzelian

Journal:

Journal of Cellular Physiology

Year:

1988

Language:

english

File:

PDF, 2.03 MB

english, 1988

5

Humanized xenobiotic response in mice expressing nuclear receptor SXR

Xie, Wen, Barwick, Joyce L., Downes, Michael, Blumberg, Bruce, Simon, Cynthia M., Nelson, Michael C., Neuschwander-Tetri, Brent A., Brunt, Elizabeth M., Guzelian, Philip S., Evans, Ronald M.

Journal:

Year:

2000

Language:

english

File:

PDF, 227 KB

english, 2000

6

Comparison of urinary 6-β-cortisol and the erythromycin breath test as measures of hepatic P450IIIA (CYP3A) activity

Guzelian, Philip S, Voorhees, John J, Watkins, Paul B, Turgeon, D Kim, Saenger, Paul, Lown, Kenneth S, Kolars, Joseph C, Hamilton, Ted, Fishman, Kenneth

Journal:

Clinical Pharmacology & Therapeutics

Year:

1992

Language:

english

File:

PDF, 684 KB

english, 1992

7

Identification of a reduced form of chlordecone (Kepone®) in human stool

Robert V. Blanke, Marc W. Fariss, Philip S. Guzelian, A. R. Paterson, Danne E. Smith

Journal:

Bulletin of Environmental Contamination and Toxicology

Year:

1978

Language:

english

File:

PDF, 176 KB

english, 1978

8

Transient induction of cytochrome P450 1A1 mRNA by culture medium component in primary cultures of adult rat hepatocytes

Thomas A. Kocarek, Erin G. Schuetz, Philip S. Guzelian

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1993

Language:

english

File:

PDF, 679 KB

english, 1993

9

Isolation of CYP3A5P cDNA from human liver: a reflection of a novel cytochrome P-450 pseudogene

John D. Schuetz, Philip S. Guzelian

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression

Year:

1995

Language:

english

File:

PDF, 566 KB

english, 1995

10

Collagen synthesis by the hepatocyte: studies in primary cultures of parenchymal cells from adult rat liver

Philip S. Guzelian, G. Dastigir Qureshi, Robert F. Diegelmann

Journal:

Collagen and Related Research

Year:

1980

Language:

english

File:

PDF, 1000 KB

english, 1980

11

Colchicine does not Provide a Sustained Blockage of Collagen and Plasma Protein Secretion by Rat Hepatocytes

Robert F. Diegelmann, Shaun Ruddy, G. Dastgir Qureshi, Philip S. Guzelian

Journal:

Collagen and Related Research

Year:

1987

Language:

english

File:

PDF, 713 KB

english, 1987

12

Characterization of a Pretranscriptional Pathway for Induction by Phenobarbital of Cytochrome P450 3A23 in Primary Cultures of Adult Rat Hepatocytes

Susan E.S. Brown, Linda C. Quattrochi, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1997

Language:

english

File:

PDF, 1.36 MB

english, 1997

13

Characterization of DNA-Binding Proteins Required for Glucocorticoid Induction of CYP3A23

Linda C. Quattrochi, Charles B. Yockey, Joyce L. Barwick, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 870 KB

english, 1998

14

Induction of hepatic heme oxygenase activity by bromobenzene

Philip S. Guzelian, Nabil A. Elshourbagy

Journal:

Archives of Biochemistry and Biophysics

Year:

1979

Language:

english

File:

PDF, 802 KB

english, 1979

15

Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes

A.Ruth Steward, Steven A. Wrighton, David S. Pasco, John B. Fagan, Donna Li, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 2.29 MB

english, 1985

16

Purification and characterization of aldo-keto reductases from gerbil liver: Immunochemical evidence for related proteins in other mammalian species

David T. Molowa, Steven A. Wrighton, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1986

Language:

english

File:

PDF, 1.10 MB

english, 1986

17

Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

John D. Schuetz, David T. Molowa, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 1.59 MB

english, 1989

18

Role of heme in phenobarbital induction of cytochromes P450 and 5-aminolevulinate synthase in cultured rat hepatocytes maintained on an extracellular matrix

Peter R. Sinclair, Erin G. Schuetz, William J. Bement, Sally A. Haugen, Jacqueline F. Sinclair, Brian K. May, Donna Li, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 1.61 MB

english, 1990

19

Divergent effects of cycloheximide on the induction of Class II and Class III cytochrome P450 mRNAs in cultures of adult rat hepatocytes

Hans-Joerg Burger, Erin G. Schuetz, John D. Schuetz, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1990

Language:

english

File:

PDF, 1.72 MB

english, 1990

20

Ethanol increases cytochromes P450IIE, IIB1/2, and IIIA in cultured rat hepatocytes

Jacqueline F. Sinclair, Jennifer McCaffrey, Peter R. Sinclair, William J. Bement, Linda K. Lambrecht, Sheryl G. Wood, E.Lucile Smith, John B. Schenkman, Philip S. Guzelian, Sang S. Park, Harry V. Gelb

Journal:

Archives of Biochemistry and Biophysics

Year:

1991

Language:

english

File:

PDF, 1.33 MB

english, 1991

21

Expression of cytochrome P450 3A in amphibian, rat, and human kidney

Erin G. Schuetz, John D. Schuetz, W.McLean Grogan, Aniko Naray-Fejes-Toth, Geza Fejes-Toth, Judy Raucy, Philip Guzelian, Kathy Gionela, Charles O. Watlington

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 3.40 MB

english, 1992

22

Studies of the formation and relase of glycerolipids by primary monolayer cultures of adult rat hepatocytes

Robert G. Lamb, Craig K. Wood, Barbara M. Landa, Philip S. Guzelian, Harold J. Fallon

Journal:

Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism

Year:

1977

Language:

english

File:

PDF, 975 KB

english, 1977

23

Identification of the cyanopregnenolone-inducible form of hepatic cytochrome P-450 as a catalyst of aldrin epoxidation

Sammye L. Newman, Philip S. Guzelian

Journal:

Biochemical Pharmacology

Year:

1983

Language:

english

File:

PDF, 315 KB

english, 1983

24

Expression of five forms of microsomal cytochrome P-450 in primary cultures of rabbit hepatocytes treated with various classes of inducers

Martine Daujat, Lydiane Pichard, Christian Dalet, Christian Larroque, Claude Bonfils, Denis Pompon, Donna Li, Philip S. Guzelian, Patrick Maurel

Journal:

Biochemical Pharmacology

Year:

1987

Language:

english

File:

PDF, 2.39 MB

english, 1987

25

Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult

Steven A. Wrighton, David T. Molowa, Philip S. Guzelian

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 431 KB

english, 1988

26

Regulation of cytochrome P450 2B1/2 genes by diallyl sulfone, disulfiram, and other organosulfur compounds in primary cultures of rat hepatocytes

Jinmei Pan, Hong Jun-Yan, Donna Li, Erin G. Schuetz, Philip S. Guzelian, Huang Weiqun, Chung S. Yang

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 1023 KB

english, 1993

27

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

Thomas A. Kocarek, Erin G. Schuetz, Philip S. Guzelian

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 775 KB

english, 1994

28

Renal and hepatic family 3A cytochromes P450 (CYP3a) in spontaneously hypertensive rats

Sidhartha S. Ghosh, Ashish K. Basu, Shobha Ghosh, Rodney Hagley, Lora Kramer, John Schuetz, W.McLean Grogan, Philip Guzelian, Charles O. Watlington

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 688 KB

english, 1995

29

Time course of the acute toxic effects of sublethal doses of chlordecone (Kepone)

John L. Egle Jr., Philip S. Guzelian, Joseph F. Borzelleca

Journal:

Toxicology and Applied Pharmacology

Year:

1979

Language:

english

File:

PDF, 294 KB

english, 1979

30

Ectopic expression of MHC class II genes (RT1.B(I) β/α) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16α-carbonitrile and dexamethasone

Braulio D. Jiménez, Lymarie Maldonado, Rolf H. Dahl, Linda C. Quattrochi, Philip S. Guzelian

Journal:

Year:

2002

Language:

english

File:

PDF, 394 KB

english, 2002

31

Rapid degradation of newly synthesized collagen by primary cultures of adult rat hepatocytes

Robert F. Diegelmann, I.Kelman Cohen, Philip S. Guzelian

Journal:

Biochemical and Biophysical Research Communications

Year:

1980

Language:

english

File:

PDF, 471 KB

english, 1980

32

BODY CLEARANCE OF HALOGENATED HYDROCARBONS: WORKSHOP SUMMARY

Philip S. Guzelian, Mary S. Wolff

Journal:

Annals of the New York Academy of Sciences

Year:

1979

Language:

english

File:

PDF, 82 KB

english, 1979

33

THE ROLE OF PLASMA PROTEINS IN THE TRANSPORT AND DISTRIBUTION OF CHLORDECONE (KEPONE®) AND OTHER POLYHALOGENATED HYDROCARBONS

Harry L. Skalsky, Marc W. Fariss, Robert V. Blanke, Philip S. Guzelian

Journal:

Annals of the New York Academy of Sciences

Year:

1979

Language:

english

File:

PDF, 393 KB

english, 1979

34

PHENOTYPIC STABILITY OF ADULT RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE

D. Montgomery Bissell, Philip S. Guzelian

Journal:

Annals of the New York Academy of Sciences

Year:

1980

Language:

english

File:

PDF, 865 KB

english, 1980

35

Localization of collagen prolyl hydroxylase to the hepatocyte: Studies in primary monolayer cultures of parenchymal cells from adult rat liver

Philip S. Guzelian, Robert F. Diegelmann

Journal:

Experimental Cell Research

Year:

1979

Language:

english

File:

PDF, 1.59 MB

english, 1979

36

Retention of clostridial collagenase by primary cultures of parenchymal cells prepared from adult rat liver

Philip S. Guzelian, Robert F. Diegelmann

Journal:

Year:

1979

Language:

english

File:

PDF, 307 KB

english, 1979

37

Rapid loss of δ-aminolevulinic acid dehydratase activity in primary cultures of adult rat hepatocytes: A new model of zinc deficiency

Philip S. Guzelian, Laurel O'Connor, Suzanne Fernandez, Winnie Chan, Philip Giampietro, Robert Desnick

Journal:

Year:

1982

Language:

english

File:

PDF, 333 KB

english, 1982

38

Growing acceptance of evidence-based toxicology (EBT) in regulatory decision making

Philip Guzelian

Journal:

Toxicology Letters

Year:

2008

Language:

english

File:

PDF, 63 KB

english, 2008

39

Convenient preparation of chlordecone alcohol (kepone alcohol) and its deuterated, tritiated and dechlorinated derivatives

Fariss, Marc W., Smith, J. Doyle, Blanke, Robert V., Guzelian, Philip S.

Journal:

Journal of Agricultural and Food Chemistry

Year:

1982

Language:

english

File:

PDF, 414 KB

english, 1982

40

The clinical toxicology of chlordecone as an example of toxicological risk assessment for man

Guzelian, Philip S.

Journal:

Toxicology Letters

Year:

1992

Language:

english

File:

PDF, 621 KB

english, 1992

41

[Part 1: Biological Sciences] || Stimulation of de novo Synthesis of Cytochrome P-450 by Phenobarbital in Primary Nonproliferating Cultures of Adult Rat Hepatocytes

Sammye Newman and Philip S. Guzelian

Journal:

Proceedings of the National Academy of Sciences

Year:

1982

Language:

english

File:

PDF, 906 KB

english, 1982

42

Sex Change in Cytochrome P-450 Phenotype by Growth Hormone Treatment of Adult Rat Hepatocytes Maintained in a Culture System on Matrigel

Philip S. Guzelian, Donna Li, Erin G. Schuetz, Paul Thomas, Wayne Levin, Agneta Mode and J.-A. Gustafsson

Journal:

Proceedings of the National Academy of Sciences

Year:

1988

Language:

english

File:

PDF, 1.09 MB

english, 1988

43

Research Needs for Hepatic Injury Due to Environmental Agents

Philip S. Guzelian

Journal:

Environmental Health Perspectives

Year:

1983

Language:

english

File:

PDF, 1.33 MB

english, 1983

44

Clinical Evaluation of Liver Structure and Function in Humans Exposed to Halogenated Hydrocarbons

Philip S. Guzelian

Journal:

Environmental Health Perspectives

Year:

1985

Language:

english

File:

PDF, 1.19 MB

english, 1985

45

Science Funding

Norma C. Barfield, Patricia A. Buffler, Doyle G. Graham, Bernadette Gray-Little, Phylis Greenberger, Philip S. Guzelian, Maureen Henderson, Rogene Henderson, Lovell Jones, Michael Lieberman, Curtis A.

Journal:

Environmental Health Perspectives

Year:

1995

Language:

english

File:

PDF, 501 KB

english, 1995

46

Stimulation of fibrinogen synthesis in cultured rat hepatocytes by fibrinogen fragment E

Qureshi, G.Dastgir, Guzelian, Philip S., Vennart, R.Marcus, Evans, Herbert J.

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

1985

Language:

english

File:

PDF, 703 KB

english, 1985

47

Transient Induction of Cytochrome P450 1A1 mRNA by Culture Medium Component in Primary Cultures of Adult Rat Hepatocytes

Thomas A. Kocarek, Erin G. Schuetz and Philip S. Guzelian

Journal:

In Vitro Cellular & Developmental Biology

Year:

1993

Language:

english

File:

PDF, 395 KB

english, 1993

48

Identification of the cytochrome P-450 induced by macrolide antibiotics in rat liver as the glucocorticoid responsive cytochrome P-450p

Wrighton, Steven A., Maurel, Patrick, Schuetz, Erin G., Watkins, Paul B., Young, Beverly, Guzelian, Philip S.

Journal:

Year:

1985

Language:

english

File:

PDF, 2.12 MB

english, 1985

49

Regulation of cytochrome P-450p by phenobarbital and phenobarbital-like inducers in adult rat hepatocytes in primary monolayer culture and in vivo

Schuetz, Erin G., Wrighton, Steven A., Safe, Stephen H., Guzelian, Philip S.

Journal:

Year:

1986

Language:

english

File:

PDF, 2.22 MB

english, 1986

50

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase

Winters, Charles J., Molowa, David T., Guzelian, Philip S.

Journal:

Year:

1990

Language:

english

File:

PDF, 3.24 MB

english, 1990